Thuli is an advocate of the High Court of South Africa, is the law trust chair in social justice and a law professor at the University of Stellenbosch, where she conducts and coordinates social justice research and teaches constitutional and administrative law. She is the founder of the Thuma Foundation, an independent democracy leadership and literacy public benefit organisation and convener of the Social Justice M-Plan, a Marshall Plan-like initiative aimed at catalysing progress towards ending poverty and reducing inequality by 2030, in line with the National Development Plan (NDP) and Sustainable Development Goals (SGGs). She is a monthly columnist for the Financial Mail and City Press/Rapport, and occasionally writes for other newspapers. In 2015, she was awarded a Doctor of Laws (LL.D.) from the University of Stellenbosch. Thuli is a Fellow of Salzburg Global Seminar.